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KMID : 1143620170210020028
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Korean Journal of Nuclear Medicine Technology
2017 Volume.21 No. 2 p.28 ~ p.30
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Evaluation of reference value of anti-Glutamic acid decarboxylase antibody for cerebrospinal fluid
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Park Min-Ho
Shin Sun-Young
Youn Tae-Seok
Shin Hi-Jung
Noh Kyeong-Woon
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Abstract
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Purpose : Anti-Glutamic acid decarboxylase antibody test (GAD Ab) has been used as a predictor of type 1 diabetes. GAD Ab has also been shown to be highly potent in cerebrospinal fluid (CSF) of patients with suspected diabetic peripheral neuropathy. Recently, it has been known that clinical significance of GAD Ab using CSF is useful for the neurological disorders. However, the reference value of anti-GAD Ab has been provided only for serum. In this experiment, we estimated the reference value of anti-GAD antibody for CSF in neurological patients.
Materials and Methods : A total of 211 neurological patients were enrolled. Serum and CSF were analyzed by radioimmunoassay (RIA) using commercial RIA anti-GAD Ab kit (RSR, London, United Kingdom). Normal saline was used as the normal CSF control because CSF is most similar to 0.9% normal saline.
Results : The mean value of normal CSF control was 1.97 U/mL, and two standard deviations (2SD) was 1.44 U/mL. Based on this data, the expected reference range of CSF could be estimated from 0.54 U/mL to 3.40 U/mL
Conclusion : The reference range of normal CSF control using normal saline obtained with Hoffmann's method. However, there will be a need to validate the CSF reference values using human normal CSF.
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KEYWORD
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Glutamic Acid Decarboxylase Antibody (GAD Ab), Cerebrospinal fluid (CSF), Radioimmunoassay (RIA)
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